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KMID : 0370220060500060429
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Yakhak Hoeji
2006 Volume.50 No. 6 p.429 ~ p.435
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The Antidepressant Effects of Cirsium japomicum in ICR Mice
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Park Hyung-Keun
Yoon Seo-Young
Choi Jong-Hyun
Ko Hong-Sook
Suh Yeon-Won
Lee Yong-Soo
Kim Gun-Hee
Chung Mi-Sook
Cheong Jae-Hoon
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Abstract
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The antidepressant effects of Cirsium japonicum compositae was investigated using open field test and forced swimming test. Total extract of Cirsium japonicum (CJ) was orally administered at dose of 20, 100, 300, 500mg/kg body weight. Supplementation of CJ increase dose-dependently movement, rearing frequency and total turn angle in the center area of open field in mice. Treatment of Cirsium japonicum’s extract (360mg/kg, CJ) decreased immobile duration and increased mobile and strong mobile duration significantly, and it is comparable to that of imipramine and fluoxetine. These results indicate that CJ has antidepressant effect. Treatment of CJ did not induced any impairment in motor coordination and myorelaxation. These results indicate that the constituents or its complex of Cirsium japonicum could be a candidate of new antidepressant drug.
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KEYWORD
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cirsium japomicum, antidepressant, forced swimming test
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